The Kleinstiver Lab

We develop genome engineering technologies for research applications and for the treatment of human diseases. Learn more about our research and the people in the lab!

The Kleinstiver Lab is located in the Center for Genomic Medicine at Massachusetts General Hospital, and the Department of Pathology at Massachusetts General Hospital and Harvard Medical School. Reach out and join us!


News + things happening in the Kleinstiver Lab


Back in the lab after shutdown!

July 2020

After a long pause on wet-lab research, we're back in the lab. Stay safe everyone!

virtual PQE celebration

April 2020

Logan Hille (Harvard BBS PhD candidate) passed his PQE (preliminary qualifying exam) this week. Congrats, Logan! 💯🎉

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The first paper from our lab published in Science!

March 2020

Our work to enable nearly complete targeting of the genome with CRISPR-Cas9 is published! Congrats to Russell (💯), Katie, and Madelynn on some truly impressive work.

Brief thread here + paper featured by Nature, MGHGEN, and genomeweb.

Keystone Engineering the Genome

February 2020

Katie travelled to Canada to present her and Russell's latest work at the Keystone 2020 Conference, held in the beautiful city of Banff, AB.

📸 cred: @JulesGrünewald


CGM Holiday Party

December 2019

Another great holiday party with the Center for Genomic Medicine @ MGH, hosted at the Liberty Hotel, Boston

Kleinstiver Lab Holiday Celebration

December 2019

Holiday party complete with creatively wrapped yankee swap gifts, lab ornaments, and our newest lab member


Join us!

Before the spring

CRISPy, the pipetting snowman, won't last forever..

Check out our open positions here!

CGM annual retreat

October 2019

Katie presents her and Russell's exciting new work at the 2019 CGM retreat!

📸cred: @salomedsdl

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We escaped!

August 2019

Our first lab outing to an escape room was a huge success (especially with 4 first-timers). Crush Depth at Trapology was great. Next: to complete all escape rooms in Boston..

"If you can cook,
you can science"

April 2019

A very belated lab holiday celebration! During our cooking class at Eataly we learned how to make fresh cavatelli pasta with a garlic, parmesan, sausage, and broccoli rabe sauce. Delizioso!

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Journal Club: Class 1 CRISPR systems

April 2019

Serendipitous day to choose papers that discuss Class 1 CRISPR systems for our Journal Club, given the recent publication from the Ke and Zhang labs (describing the use of Cas3 for long-range genome editing in human cells). Assist from the IGI with the CRISPR cards.

We're hiring!

March 2019

We are recruiting motivated researchers for a Research Technician I or II position. This is a great opportunity to gain 2 years of research experience in the genome editing field, especially for those who are looking for additional training prior to applying to graduate school. Link to application here. 


Fancy new lab logo

March 2019

Science animator extraordinaire Joy Horng helps us design our new lab logo - thanks!

Let us know what you think!

Cas12a paper published!

February 2019

Our work describing enhanced Cas12a variants, done in the Joung Lab, published in Nature Biotechnology! Thanks to all in the Joung lab and collaborators at MGH who made this possible! Special acknowledgement to Alex and Russell who worked day (and night) for a long time for this one.

Paper featured in pieces by GEN and genomeweb.


Harold B Stewart Lecture

January 2019

Lab work begins!

November 2018

All stocked up and ready to go..


Poster Award!

October 2018

Russell wins a Poster of Distinction Award at MGH Clinical Research Day - congrats Russell!

CGM Annual Retreat

September 2018

Russell presents a 60-second lightning talk on genome editing and Cas12a!
+ Ben gave a seminar on all things planned for the Kleinstiver Lab.


Here we go!

September 2018

A blank canvas, soon to be full


Reach out!

The Kleinstiver Lab is located in the Center for Genomic Medicine at Massachusetts General Hospital (MGH), and the Departments of Pathology at MGH and Harvard Medical School (HMS).

Inquiries should be directed to Ben Kleinstiver:

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Center for Genomic Medicine

Massachusetts General Hospital & Harvard Medical School

Simches Research Building

185 Cambridge St.

Boston, MA, USA

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