The Kleinstiver Lab
We develop genome engineering technologies for research applications and for the treatment of human diseases. Learn more about our research and the people in the lab!
The Kleinstiver Lab is located in the Center for Genomic Medicine at Massachusetts General Hospital, and the Department of Pathology at Massachusetts General Hospital and Harvard Medical School. Reach out and join us!
News & things happening in the Kleinstiver Lab
Farewell Ann-Sophie! 🔬🏓
We really enjoyed having you in the lab! #quiddditchchampion
A productive winter for the lab
Congrats to Chris on receiving several grants, and to Emily for passing her PQE & an NSF honorable mention. The lab was also awarded an MGH Research Scholar Award. And special thanks to Jo for making this lab cartoon 🙏😀.
"CRISPR Anywhere" a top technology to watch in 2023
A fitting day for Russell to finally receive his very belated framed cover art, as Nature featured his work developing SpRY as one of "Seven Technologies to Watch in 2023". Amazing work, congrats Russell!
🧬 Two papers published to start the year 🎉
Our manuscript describing HELIX to improve several properties of CRISPR-associated transposases published in Nature Biotechnology. See Connor's tweetorial and blog post.
We also contributed to an international collaboration on ancestral Cas enzymes (with data and analysis by Logan and Rachel).
Congrats to all co-authors 😃🥂
Lab get together 🍴
A night of pasta 🍝 and spicy chips 🔥 to celebrate an exciting fall in the lab!
Annual Retreat for our Center
Chris and Connor presented posters on their new exciting work at our CGM retreat (hosted at Broad institute)!
🎃 Happy Halloween 👻
Spooky in the Kleinstiver lab with Laa-Laa, TInky-Winky, Po, Sun Baby, and Dipsy
🧬 SpRYgest manuscript published 🧬
Our manuscript describing the use of SpRY for DNA digests (SpRYgests) published in Nature Biotechnology. See Katie's tweetorial and news here, here, and here. Congrats all 😃🍻
NIH Director's New Innovator (DP2) Award
The lab was fortunate to receive an NIH grant! These funds will enable us to continue our work developing innovative genome editing technologies. More news here and here.
Lab bday celebrations 🎂
A month full of birthdays and other things to celebrate!! 🥳
📣 DSB-free kb-scale edits 📣
Connor's perspective piece on recent technology developments for large sequence edits published in Biochemistry
AJ gave an excellent presentation to the CGM, summarizing his summer project in the lab! Thanks for joining us, AJ!
Ice cream 🍦 for Jo's #scoopversary
A worthy celebration of Jo's path to her great paper on DNA repair determinants of prime editing. Read more about the 🍦celebration here!
Pizza @ Area Four
Celebrating AJ's summer internship, Jake's rotation, and Chris's fellowship!
Spring lab outing!
Successfully escaped both rooms at PanIQ! 🕵️ 🔎
Farewell, KAC! 🎉
Sending off the last Kleinstiver Lab OG with Korean food 🥘, a round of the Friends game, and a special 🐷. Best of luck in your new role at ScribeTx, Katie!
2021 Holiday Party
December 2021 🌟
Yankee Swap, games, and sushi 🍱
So Ultra 🏃
October 2021 🎃
The Kleinstiver Lab watched in awe as Connor fulfilled his life goal of pipetting and crushing a marathon at the same time
Farewell, Roman! 👨🔬
Best oof luck on your next adventures, we'll miss you!
Patio lunch for Logan's Bday 🎈
Complete with a bacon-wrapped, cheese- and sausage-stuffed, sausage. Amazing creation, Rachel! 🥓
Delicious Ube Mochi Cake for Connor's Bday 🎉
Thanks to Katie and Rachel for this tasty treat!! 🎂
Congrats to Esaria and the rest of the Eckerd College interns for a productive summer in the CGM!
Farewell BBQ for Madelynn!
Wishing Madelynn all the best as she moves on to start grad school at U Penn in the fall!
Inaugural Kleinstiver Lab retreat
Off for our first lab retreat in Provincetown for a day packed with exploring and eating!
Now Open 🎨
The Kleinstiver Lab Art Gallery of Modern CRISPR Art is now open! Visits by appointment only.
A well-deserved celebration for Rachel passing her PQE!
Happy St. Patrick's Day! 🍀
The lab receives an award!
We're honored to receive this GenScript Distinguished Research Award, especially to share it with a distinguished scientist like Dr. Caixia Gao! Kudos and thanks to my lab, and all our colleagues, friends, and family who voted for us!! See more *here*
Back in the lab after shutdown!
After a long pause on wet-lab research, we're back in the lab. Stay safe everyone!
virtual PQE celebration
Logan Hille (Harvard BBS PhD candidate) passed his PQE (preliminary qualifying exam) this week. Congrats, Logan! 💯🎉
The first paper from our lab published in Science!
Our work to enable nearly complete targeting of the genome with CRISPR-Cas9 is published! Congrats to Russell (💯), Katie, and Madelynn on some truly impressive work.
Brief thread here + paper featured by Nature, MGH, GEN, and genomeweb.
Keystone Engineering the Genome
Katie travelled to Canada to present her and Russell's latest work at the Keystone 2020 Conference, held in the beautiful city of Banff, AB.
📸 cred: @JulesGrünewald
CGM Holiday Party
Another great holiday party with the Center for Genomic Medicine @ MGH, hosted at the Liberty Hotel, Boston
Kleinstiver Lab Holiday Celebration
Holiday party complete with creatively wrapped yankee swap gifts, lab ornaments, and our newest lab member
Before the spring
CRISPy, the pipetting snowman, won't last forever..
Check out our open positions here!
CGM annual retreat
Katie presents her and Russell's exciting new work at the 2019 CGM retreat!
Our first lab outing to an escape room was a huge success (especially with 4 first-timers). Crush Depth at Trapology was great. Next: to complete all escape rooms in Boston..
"If you can cook,
you can science"
A very belated lab holiday celebration! During our cooking class at Eataly we learned how to make fresh cavatelli pasta with a garlic, parmesan, sausage, and broccoli rabe sauce. Delizioso!
Journal Club: Class 1 CRISPR systems
Serendipitous day to choose papers that discuss Class 1 CRISPR systems for our Journal Club, given the recent publication from the Ke and Zhang labs (describing the use of Cas3 for long-range genome editing in human cells). Assist from the IGI with the CRISPR cards.
We are recruiting motivated researchers for a Research Technician I or II position. This is a great opportunity to gain 2 years of research experience in the genome editing field, especially for those who are looking for additional training prior to applying to graduate school. Link to application here.
Fancy new lab logo
Science animator extraordinaire Joy Horng helps us design our new lab logo - thanks!
Let us know what you think!
Cas12a paper published!
Our work describing enhanced Cas12a variants, done in the Joung Lab, published in Nature Biotechnology! Thanks to all in the Joung lab and collaborators at MGH who made this possible! Special acknowledgement to Alex and Russell who worked day (and night) for a long time for this one.
Harold B Stewart Lecture
Ben was honored to present the Harold B. Stewart Lecture, back where he did his PhD in the Department of Biochemistry at Western University.
Lab work begins!
All stocked up and ready to go..
Russell wins a Poster of Distinction Award at MGH Clinical Research Day - congrats Russell!
CGM Annual Retreat
Russell presents a 60-second lightning talk on genome editing and Cas12a!
+ Ben gave a seminar on all things planned for the Kleinstiver Lab.
Here we go!
A blank canvas, soon to be full