The Kleinstiver Lab
We develop genome engineering technologies for research applications and for the treatment of human diseases. Learn more about our research and the people in the lab!
The Kleinstiver Lab is located in the Center for Genomic Medicine at Massachusetts General Hospital, and the Department of Pathology at Massachusetts General Hospital and Harvard Medical School. Reach out and join us!
News + things happening in the Kleinstiver Lab
Farewell BBQ for Madelynn!
July 2021
Wishing Madelynn all the best as she moves on to start grad school at U Penn in the fall!
Inaugural Kleinstiver Lab retreat
July 2021
Off for our first lab retreat in Provincetown for a day packed with exploring and eating!
Now Open 🎨
June 2021
The Kleinstiver Lab Art Gallery of Modern CRISPR Art is now open! Visits by appointment only.
Congrats Rachel!
June 2021
A well-deserved celebration for Rachel passing her PQE!
#luckylogan
March 2021
Happy St. Patrick's Day! 🍀
The lab receives an award!
March 2021
We're honored to receive this GenScript Distinguished Research Award, especially to share it with a distinguished scientist like Dr. Caixia Gao! Kudos and thanks to my lab, and all our colleagues, friends, and family who voted for us!! See more *here*
Join us!!
January 2021
Plant genome editing branches out
January 2021
Logan's News & Views piece, writing about the use of SpRY in plants, published in Nature Plants! See *here*
Back in the lab after shutdown!
July 2020
After a long pause on wet-lab research, we're back in the lab. Stay safe everyone!
virtual PQE celebration
April 2020
Logan Hille (Harvard BBS PhD candidate) passed his PQE (preliminary qualifying exam) this week. Congrats, Logan! 💯🎉
The first paper from our lab published in Science!
March 2020
Our work to enable nearly complete targeting of the genome with CRISPR-Cas9 is published! Congrats to Russell (💯), Katie, and Madelynn on some truly impressive work.
Brief thread here + paper featured by Nature, MGH, GEN, and genomeweb.
Keystone Engineering the Genome
February 2020
Katie travelled to Canada to present her and Russell's latest work at the Keystone 2020 Conference, held in the beautiful city of Banff, AB.
📸 cred: @JulesGrünewald
CGM Holiday Party
December 2019
Another great holiday party with the Center for Genomic Medicine @ MGH, hosted at the Liberty Hotel, Boston
Kleinstiver Lab Holiday Celebration
December 2019
Holiday party complete with creatively wrapped yankee swap gifts, lab ornaments, and our newest lab member
Join us!
Before the spring
CRISPy, the pipetting snowman, won't last forever..
Check out our open positions here!
CGM annual retreat
October 2019
Katie presents her and Russell's exciting new work at the 2019 CGM retreat!
📸cred: @salomedsdl
We escaped!
August 2019
Our first lab outing to an escape room was a huge success (especially with 4 first-timers). Crush Depth at Trapology was great. Next: to complete all escape rooms in Boston..
"If you can cook,
you can science"
April 2019
A very belated lab holiday celebration! During our cooking class at Eataly we learned how to make fresh cavatelli pasta with a garlic, parmesan, sausage, and broccoli rabe sauce. Delizioso!
Journal Club: Class 1 CRISPR systems
April 2019
Serendipitous day to choose papers that discuss Class 1 CRISPR systems for our Journal Club, given the recent publication from the Ke and Zhang labs (describing the use of Cas3 for long-range genome editing in human cells). Assist from the IGI with the CRISPR cards.
We're hiring!
March 2019
We are recruiting motivated researchers for a Research Technician I or II position. This is a great opportunity to gain 2 years of research experience in the genome editing field, especially for those who are looking for additional training prior to applying to graduate school. Link to application here.
Fancy new lab logo
March 2019
Science animator extraordinaire Joy Horng helps us design our new lab logo - thanks!
Let us know what you think!
Cas12a paper published!
February 2019
Our work describing enhanced Cas12a variants, done in the Joung Lab, published in Nature Biotechnology! Thanks to all in the Joung lab and collaborators at MGH who made this possible! Special acknowledgement to Alex and Russell who worked day (and night) for a long time for this one.
Harold B Stewart Lecture
January 2019
Ben was honored to present the Harold B. Stewart Lecture, back where he did his PhD in the Department of Biochemistry at Western University.
Lab work begins!
November 2018
All stocked up and ready to go..
Poster Award!
October 2018
Russell wins a Poster of Distinction Award at MGH Clinical Research Day - congrats Russell!
CGM Annual Retreat
September 2018
Russell presents a 60-second lightning talk on genome editing and Cas12a!
+ Ben gave a seminar on all things planned for the Kleinstiver Lab.
Here we go!
September 2018
A blank canvas, soon to be full
Reach out!
The Kleinstiver Lab is located in the Center for Genomic Medicine at Massachusetts General Hospital (MGH), and the Departments of Pathology at MGH and Harvard Medical School (HMS).
Inquiries should be directed to Ben Kleinstiver: